Protective effect of Isoliquiritigenin on skin ischemia-reperfusion injury in rats

Abstract Skin ischemia-reperfusion (I/R) injury is a serious condition that compromises skin flap surgery and leads to organ dysfunction. It arose due restoration of blood supply after prolonged ischemia. The present study was conducted explore the possible protective Isoliquiritigenin (ISL) on in rats. ISL administered rats dose 10 mg/kg, 20 30 mg/kg. effect quantified tissue following I/R various indices inflammation, oxidative stress, apoptosis together with survival. improves survival which further confirmed by histopathological analysis. also causes reduction as shown TUNEL staining. level stress found significantly reduced restoring MDA, SOD, GSH levels near normal. inflammation decreased suggested cytokines, such TNF-α, IL-1β, IL-6. significant COX-2 iNOS western blot Collectively, our has beneficial against via multiple mechanisms action, attenuation apoptosis.